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Enzyme patterns in mitochondria of mouse liver and heart muscle

✍ Scribed by Kistler, Andreas ;Weber, Rudolf

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
695 KB
Volume
184
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

The content of membrane‐bound (COX, SDH) and matrix enzymes (MDH, GOT, GDH) in mitochondria of heart muscle and liver of the mouse has been compared. Ageing of osmotically lysed liver mitochondria has little effect on enzyme stability, except for GDH the activity of which drops by 40%. Purification of liver mitochondria by sucrose density‐gradient centrifugation results in a loss of COX‐activity of 70%, but has no effect on cytochrome aa~3~ content. Heart muscle mitochondria are characterized by higher activities (per unit mitochondrial protein) of SDH, MDH, GOT and cytochrome aa~3~ content, but lower levels of GDH activity as compared to liver mitochondria. When referred to cytochrome aa~3~ content “constant activity proportions” are noted for SDH, MDH and GOT, whilst “specific activity proportions” are characteristic of GDH. The enzyme patterns are compared to the ultrastructure of these mitochondria.

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