Enzyme-linked immunosorbent assays for antibodies to poly(A), poly dAT and histones: possibly useful tools for the evaluation of prognosis and disease activity in systemic lupus erythematosus

Antibodies to histones and disease activ

Antibodies to histones and disease activity in systemic lupus erythematosus: A comparative study with an enzyme-linked immunosorbent assay and immunoblotting

✍ K. Konstantinov; V. Russanova; V. Russeva 📂 Article 📅 1986 🏛 Springer-Verlag 🌐 English ⚖ 811 KB

Enzyme-linked immunosorbent assay (ELISA) and immunoblotting were used to define comparatively the frequency of antibodies to total histones and different histone fractions -HI, H2A, H2B, H3, and H4 -in 16 patients with idiopathic systemic lupus erythematosns. HI and H2B showed the most prominent an