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Enzyme Inhibition by Allicin, the Molluscicidal Agent of Allium sativum L. (Garlic)

✍ Scribed by V. K. Singh; D. K. Singh

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 367 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199608)10:5<383::aid-ptr855>3.0.co;2-9

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✦ Synopsis

Allicin, a molluscicidal component of garlic inhibited the activity of acetylcholinesterase, lactic dehydrogenase and alkaline phosphatase in in vivo and in vitro exposure against Lymnaea acuminata. It was observed that succinic dehydrogenase activity in the nervous tissue of Lymnaea acuminata was increased in in vivo treatment whereas with in vitro exposure, allicin caused no significant change in succinic dehydrogenase activity. The inhibition kinetics of these enzymes indicates that allicin caused an uncompetitive inhibition of AChE and a competitive inhibition of LDH and alkaline phosphatase.