Enzyme Induction and Modulation
β Thomas D. Gelehrter, Patricia A. Barouski-Miller, Patrick L. Coleman, Bernard J.
π Library
π
1983
π Springer US
π English
β¦ LIBER β¦
π
Enzyme Induction
β Scribed by Alan Wiseman (auth.), Dennis V. Parke (eds.)
- Publisher
- Springer US
- Year
- 1975
- Tongue
- English
- Leaves
- 332
- Series
- Basic Life Sciences 6
- Edition
- 1
- Category
- Library
β¬ Acquire This Volume
No coin nor oath required. For personal study only.
β¦ Synopsis
Our present concepts ofthe regulation of enzyme activity in the cell have been largely based on the extensive body of work which has been carried out with micro-organisms. A distinction between constitutive and adaptive enzymes had already been made well before World War II and work on enzyme adaptation, both in yeast and bacteria, was done by several workers, especially Marjorie Stephenson and her group in Cambridge in the 1930s. In studies starting about 1947 Stanier demonstrated that the oxidation of aromatic compounds by species of Pseudomonas involved the coordinate and sequential induction of a group of enzymes concerned in the orderly catabolism of a substrate which acted as the inducer. The investigations of Umbarger and of Pardee, both in 1956, established the principle, which is now firmly established for almost all anabolic reaction chains, that the first 'committed' step in a biosynthetic pathway is sensitive to feedback control by the final product of the particular reaction sequence. This control can be exercised in two ways. It can either act on the rate of formation of the enzyme or it can affect the activity of the latter without altering the concentration of the enzyme.
β¦ Table of Contents
Front Matter....Pages i-xii
Enzyme Induction in Microbial Organisms....Pages 1-26
Enzyme Induction in the Process of Development....Pages 27-77
Mechanism of Steroid Hormone Action at the Cellular Level....Pages 79-104
Action of Aldosterone on Transepithelial Sodium Transport....Pages 105-141
Enzyme Induction by Steroid Hormones with Reference to Cancer....Pages 143-168
The Control of Tryptophan Metabolism....Pages 169-184
The Effect of Drugs on 5-Aminolaevulinate Synthetase and Other Enzymes in the Pathway of Liver Haem Biosynthesis....Pages 185-205
Induction of the Drug-Metabolizing Enzymes....Pages 207-271
Clinical Implications of Enzyme Induction....Pages 273-301
Disruptions in Enzyme Regulation during Aging....Pages 303-311
Back Matter....Pages 313-328
β¦ Subjects
Animal Anatomy / Morphology / Histology
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