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Enzyme-Catalyzed Synthesis of a Novel Thermosensitive Polyester with Pendant Ketoprofen

โœ Scribed by Hai-Yang Wang; Yu-Jie Zhou; Zao Wang; Na Wang; Kun Li; Xiao-Qi Yu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
287 KB
Volume
11
Category
Article
ISSN
1616-5187

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โœฆ Synopsis

Abstract

A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2โ€ketoprofendimethylmalate using CALโ€B at 70โ€‰ยฐC. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug. magnified image

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.