𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enzyme-Catalyzed Ring-Opening Polymerization of Unsubstituted β-Lactam

✍ Scribed by Leendert W. Schwab; Renee Kroon; Arend Jan Schouten; Katja Loos

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
123 KB
Volume
29
Category
Article
ISSN
1022-1336

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of poly(β‐alanine) by Candida antarctica lipase B immobilized as novozyme 435 catalyzed ring‐opening of 2‐azetidinone is reported. After removal of cyclic side products and low molecular weight species pure linear poly(β‐alanine) is obtained. The formation of the polymer is confirmed with ^1^H NMR spectroscopy and MALDI‐TOF mass spectrometry. The average degree of polymerization of the obtained polymer is limited to $\overline {DP}$ = 8 by its solubility in the reaction medium. Control experiments with β‐alanine as a substrate confirmed that the ring structure of the 2‐azetidinone is necessary to obtain the polymer.

magnified image

📜 SIMILAR VOLUMES

ChemInform Abstract: Novel Enzyme-Cataly
ChemInform Abstract: Novel Enzyme-Catalyzed Ring-Opening Polymerization of Glycidol.
✍ Yasuyuki Soeda; Kazunobu Toshima; Shuichi Matsumura 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 24 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Lipase-catalyzed ring-opening polymeriza
Lipase-catalyzed ring-opening polymerization of lactide
✍ Shuichi Matsumura; Kimihiro Mabuchi; Kazunobu Toshima 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB

## Abstract The six‐membered lactide was polymerized using the ring‐opening polymerization with lipase as a catalyst at a temperature between 80 and 130°C in bulk to yield the corresponding polylactide with weight‐average molecular weights of up to 126000. The most preferable conditions with respec

Synthesis of metal-free poly(1,4-dioxan-
Synthesis of metal-free poly(1,4-dioxan-2-one) by enzyme-catalyzed ring-opening polymerization
✍ Haruo Nishida; Mitsuhiro Yamashita; Masumi Nagashima; Takeshi Endo; Yutaka Tokiw 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 2 views

To avoid the harmful effects of metallic residues in poly(1,4-dioxan-2-one) (PPDO) for medical applications, the enzymatic polymerization of 1,4-dioxan-2-one (PDO) was carried out at 60 °C for 15 h with 5 wt % immobilized lipase CA. The lipase CA, derived from Candida antarctica, exhibited especiall