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Enzyme catalysed resolution of 1,3-diarylpropan-1,3-diols

✍ Scribed by F. Levayer; C. Rabiller; C. Tellier

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 435 KB
Volume: 6
Category: Article
ISSN: 0957-4166
DOI: 10.1016/0957-4166(95)00212-8

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✦ Synopsis

Candida Rugosa Lipase (AY 30, Amano) is shown to be a very efficient catalyst for the resolution of enantiomeric 1,3-diaryl-1,3-diols by means of the transesterification reaction using vinyl acetate as an acyl donor. This enzyme also exerts a great diasteroselectivity and a pronounced regioselectivity in the monoacylation reaction of these cliols.

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