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Enzyme activities and activity profiles in muscle fibers of dystrophic, immature-normal, and adult-normal BL6 mice

✍ Scribed by Heinz Reichmann; Dr. Dirk Pette

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
542 KB
Volume
7
Category
Article
ISSN
0148-639X

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✦ Synopsis

Enzyme activities of energy metabolism were determined in both homogenates and single fibers of immature-normal (IN), adult-normal (AN), and adult-dystrophic (AD) tibialis anterior (TA) muscle of BL6 mice. Mitochondria1 enzyme activities were similar in AN and AD, whereas lower activities were found in IN. Creatine kinase, glycogenolytic, and glycolytic enzyme activities were reduced but glucose 6phosphate dehydrogenase was elevated in AD and IN as compared to AN. IN and AD both showed an increase in the H-subunit of lactate dehydrogenase. Microphotometric measurements of succinate dehydrogenase (SDH) revealed large fiber differences in AN whereas smaller scattering was observed both in IN and AD. Although similarities exist between enzyme and isozyme patterns of anaerobic metabolism in AD and IN, this does not hold for mitochondrial enzymes.

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