Enzymatic Synthesis of Enantiopure Ξ±- an
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Bian Wu; Wiktor Szymanski; Piet Wietzes; Stefaan de Wildeman; Gerrit J. Poelaren
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Article
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2009
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John Wiley and Sons
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English
β 254 KB
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## Abstract The phenylalanine aminomutase (PAM) from __Taxus chinensis__ catalyses the conversion of Ξ±βphenylalanine to Ξ²βphenylalanine, an important step in the biosynthesis of the __N__βbenzoyl phenylisoserinoyl sideβchain of the anticancer drug taxol. Mechanistic studies on PAM have suggested th