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Enzymatic synthesis of chiral intermediates for pharmaceuticals

✍ Scribed by Ramesh Patel; Ronald Hanson; Animesh Goswami; Venkata Nanduri; Amit Banerjee; Mary-Jo Donovan; Steven Goldberg; Robert Johnston; David Brzozowski; Thomas Tully; Jeffrey Howell; Dana Cazzulino; Rapheal Ko

Book ID: 106308907
Publisher: Springer-Verlag
Year: 2003
Tongue: English
Weight: 348 KB
Volume: 30
Category: Article
ISSN: 1476-5535
DOI: 10.1007/s10295-003-0032-6

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## Abstract Two lipases, Novozyme 435 (lipase B from Candida Antarctica) and Lipozyme TL IM (Thermomyces lanuginosus) were used successfully for the kinetic resolution of racemic 1-(2-furyl)-3-pentanol, the key intermediate in synthesis of the bark beetle pheromone, chalcogran. The desired S-(+)-en