Enzymatic synthesis of cephalexin in aqu
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Dong-Zhi Wei; Jian-Hang Zhu; Xue-Jun Cao
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Article
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2002
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Elsevier Science
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English
β 77 KB
Cephalexin was synthesized in aqueous two-phase systems (ATPSs) by using penicillin G acylase (PGA) (penicillin amidohydrolase, EC3.5.1.11) as a catalyst and 7-aminodeacetoxicephalosporanic acid (7-ADCA) and phenylglycine methyl ester (PGME) as substrates. In the ATPS composed of 20% (w/w) PEG 400 a