Enzymatic resolution of α-tetralols by CALB-catalyzed acetylation
✍ Scribed by Helena M.C. Ferraz; Graziela G. Bianco; Carla C. Teixeira; Leandro H. Andrade; André L.M. Porto
- Book ID
- 108284220
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 241 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0957-4166
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The lipase-catalyzed acetylation of a broad spectrum of configurations of the 2-hydroxy acids 1 were assigned by comparison of the gas-chromatographic data with that of racemic 2-hydroxy acids 1 to their 2-acetoxy acids 2 was shown to proceed with high enantioselectivity. Thus, the literature-known
An enzymatic method for the direct resolution of propranolol is described. Candida cylindracea lipase enantioselectively catalyzed N-acetylation of S-propranolol with isopropenyl acetate in isopropyl ether. The ee values of the two enantiomers of N-acetylpropranolol were determined by an HPLC equip