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Enzymatic Reduction of Oxysterols Impairs LXR Signaling in Cultured Cells and the Livers of Mice

โœ Scribed by Wenling Chen; Guoxen Chen; Daphne L. Head; David J. Mangelsdorf; David W. Russell


Book ID
116372519
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
430 KB
Volume
5
Category
Article
ISSN
1550-4131

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Age declines liver functions, leading to the development of age-associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of glucose homeostasis and fat metabolism. Because aging livers have alterations in glucose and fat metabolism, we examined a possible role of SIRT1