Enzymatic peptide synthesis in frozen aqueous systems: Use of Nα-unprotected unusual acyl donors

Enzymatic Peptide Synthesis in Frozen Aq

Enzymatic Peptide Synthesis in Frozen Aqueous Solution: Use of Nα-unprotected Peptide Esters as Acyl Donors

✍ Sabine Gerisch; Hans-Dieter Jakubke 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

The ability of the endopeptidase a-chymotrypsin (EC 3.4.21.1) to catalyse the reaction of various N aunprotected di-and tripeptide ester derivatives with H-Leu-NH 2 , and with a series of C-terminal free di-and tripeptides at ÿ15 C in frozen aqueous solution was investigated. The enzyme is able to s