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Enzymatic hydrolysis of γ-glutamyl polypeptide and its derivatives

✍ Scribed by Jacob Kream; Blanche A. Borek; C.Joseph DiGrado; Max Bovarnick


Book ID
118840380
Publisher
Elsevier Science
Year
1954
Tongue
English
Weight
414 KB
Volume
53
Category
Article
ISSN
0003-9861

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Many carcinomas in humans are rich in gamma-glutamyl transpeptidase (GGT), a plasma membrane enzyme that reacts with extracellular substrates. Thus, biochemical targeting of chemotherapeutic agents may be achieved by converting anticancer drugs into their gamma-glutamyl derivatives. Chemical convers