Enzymatic esterification of 1-ferrocenylethanol: An alternate approach to chiral ferrocenyl bis-phosphines

✍ Scribed by Neil W. Boaz

• Book ID: 104244795
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 271 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)93711-6

✦ Synopsis

Summaty-I-Femxenylethanol was enzymatically esteritied with high R-enantioselectivity by the lipase from Pseudomdnasflwrescens, indicating that this organometallic compound behaves similarly to organic analogs within the enzyme active site (according to an active site model). Efficient separation of the enantiomers was effected by selective reaction of the ester with dimethylamine followed by simple aqueous acid extraction.