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Enzymatic enantioselective hydrolysis of 2,2-dimethyl-1,3-dioxolane-4-carboxylic esters

✍ Scribed by M. Pottie; J. Van der Eycken; M. Vandewalle; J.M. Dewanckele; H. Röper


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
256 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis


2,2-Dimethyl-I,3-dioxolane-4-carboxylic acid derived chiral building blocks were prepared from substituted a&unsaturated acids with high enantiomeric purities by enzymatic hydrolysis of their n.butyl esters.


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The relative stereochemistry of the title compound, C~16~H~22~N~4~O~2~, a key intermediate in the synthesis of 3-deoxy imino sugars, was firmly established by X-ray crystallographic analysis. The absolute configuration was inferred from the starting material, D-galactose. There are no unusual crysta