Enzymatic and chromatographic chiral discrimination of racemic (thio)glycidyl esters: Part II. Optical resolution of racemic (thio)glycidyl esters on modified cellulose chiral stationary phases

✍ Scribed by Dr. Jürgen Wagner; Ulrike Offhauss; Arnim A. Martin

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 292 KB
• Volume: 5
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.530050413

✦ Synopsis

Chiral chromatography on cellulose tris(3,5-dimethylphenyl carbamate) (Chiralcel OD) and cellulose tribenzoate (Chiralcel OB) coated stationary phases has been successfully used for the optical resolution of rac-(thi0)glycidyl esters (acetate, propionate, butyrate). Glycidyl esters could sufficiently be resolved on the OD column whereas for the thio analogues baseline resolution is obtained on CSP OB using hexane/2-propanol mobile phases. The separation factor (a) and resolution (Rs) depend on column temperature, eluent composition, and flow rate, respectively. Best results were obtained for the butyrates and at low temperatures in general.