Enzymatic alcoholysis of alkoxymethyl alkanoates: a possible approach for the kinetic resolution of tertiary alcohols

✍ Scribed by Maurice C.R. Franssen; Earl L.V. Goetheer; Hugo Jongejan; Aede de Groot

• Book ID: 104260084
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 225 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01840-1

✦ Synopsis

The pivaloyloxymethyl and butanoyloxymethyl derivatives of tert-butanol and linalool (1, 4) are readily accepted by hydrolases. Linalool derivative 4b is alcoholysed stereoselectively by Candida rugosa lipase (E=9.7).