Enzymatic activities affecting exogenous nicotinamide adenine dinucleotide in human skin fibroblasts
โ Scribed by Maria Francesca Aleo; Silvia Sestini; Giuseppe Pompucci; Augusto Preti
- Book ID
- 101262394
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 481 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0021-9541
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The effects of oxidative stress on DNA damage and associated reactions, increased polyadenosine diphosphate-ribose polymerase (PARP) activity and decreased nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP) contents, have been tested in primary cultures of porcine aortic endoth
In this report we showed that calmodulin antagonists chlorpromazine (CPZ) and W-7 (N-[6-aminohexyl]-5-chloro-l-naphtalenesulfonamide), when added to fibroblast cell cultures, gave rise to a time-and dosedependent decrease of sphingomyelinase activity. CPZ and W-7 also significantly inhibited LDL-and