New findings on degradation of famotidin
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Saranjit Singh; Sanjeev Kumar; Nishi Sharda; Asit K. Chakraborti
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Article
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2002
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John Wiley and Sons
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English
⚖ 104 KB
The degradation behavior of famotidine (1) was investigated in 25% ammonia solution and in 2 M NaOH. The hydrolysis of the drug in ammonia resulted in separation of [3-[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propionamide (3), an impurity listed in British Pharmacopoeia. The treatment w