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Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease

✍ Scribed by Faneng Sun; Arthi Kanthasamy; Vellareddy Anantharam; Anumantha G. Kanthasamy

Book ID: 113845819
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 854 KB
Volume: 114
Category: Article
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2007.04.001

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## Abstract The ubiquitin–proteasome system (UPS) is the major proteolytic pathway that degrades intracellular proteins in a regulated manner. Deregulation of the UPS has been implicated in the pathogenesis of many neurodegenerative disorders like Alzheimer's disease, Parkinson's diseases, Huntingt