Environmental influence on T cell receptor α gene rearrangement and expression in vitro
✍ Scribed by Mark Larché; Samantha D. Rencher; Julia L. Hurwitz
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 429 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Restricted onset of T cell receptor a gene rearrangement in fetal and neonatal thymocytes The initial T cell receptor (TCR) a gene rearrangements were analyzed in fetal and neonatal thymocyte hybridomas by Southern blotting. Interestingly, in 30 % of all thymocyte hybridomas and in all fetal da
## Abstract The earliest T precursor population in the adult mouse thymus, considered to have the surface phenotype CD4^lo^8^−^3^−^44^+^25^−^Thy‐1^lo^ c‐kit^+^ (termed the low CD4 precursor), has been shown to have the capacity to produce B cells and dendritic cells, as well as T cells, and to have