Environmental influence on experimental teratocarcinogenesis in testes of mice

✍ Scribed by Stevens, Leroy C.

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 516 KB
• Volume: 174
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1401740405

✦ Synopsis

Abstract

Testicular teratomas were experimentally produced in mice of strains 129, A/He, and their F~1~ hybrids. When male genital ridges from 12‐ or 13‐day fetuses were grafted to various sites in adults, they developed into testes and some of them had teratomas. When male genital ridges were grafted into sites which descend into the scrotum, (the testis, the epididymis, or the epididymal fat pad of intact or castrate males), they developed into testes most of which contained teratomas. When genital ridges were grafted into sites which do not descend into the scrotum (the kidney, spleen, liver, cryptorchid testis, and ovarian fat pad) they developed into testes and most of them did not have teratomas. When genital ridges were grafted into intact females or into castrate females injected daily with peanut oil or with a physiological dose of testosterone proprionate, the incidence of teratomas was very low. These results are in accord with the hypothesis that the lower temperature in the scrotum promotes teratocarcinogenesis in grafted genital ridges. None of our results suggest that testicular or ovarian hormones of host origin are involved.