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Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

โœ Scribed by Kristin Eiklid; Sjur Olsnes; Alexander Pihl


Book ID
118877656
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
842 KB
Volume
126
Category
Article
ISSN
0014-4827

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Properties and action mechanism of the t
โœ Olsnes, Sjur ;Sandvig, Kirsten ;Eiklid, Kristin ;Pihl, Alexander ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 604 KB

The toxic lectin modeccin, which inhibits protein synthesis in eukaryotic cells, is cleaved upon treatment with 2-mercaptoethanol into two peptide chains which move in polyacrylamide gels at rates corresponding to molecular weights 28,000 and 38,000. After reduction, the toxin loses its effect on ce