Entropy Is the Major Driving Force for Fragmentation of Proteins and Protein−Ligand Complexes in the Gas Phase
✍ Scribed by Laskin, Julia; Futrell, Jean H.
- Book ID
- 126439014
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 62 KB
- Volume
- 107
- Category
- Article
- ISSN
- 1089-5639
No coin nor oath required. For personal study only.
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A theoretical study on the stability of the salt bridges in the gas phase, in solution, and in the interior of proteins is presented. The study is mainly focused on the interaction between acetate and methylguanidinium ions, which were used as model compounds for the salt bridge between Asp (Glu) an
Protein dynamics are the key to understanding their behavior. The static protein structure alone in most cases is insufficient to describe the vast array of complex functions they perform in vivo. Until recently there were relatively few techniques available to investigate the dynamic nature of thes