Entrapment of reagents in polymeric materials. Indirect atomic absorption spectrometric determination of isoniazid by oxidation with manganese dioxide incorporated in polyester resin beads in a flow-injection system

✍ Scribed by L. Lahuerta Zamora; J.V. Garcia Mateo; J. Martinez Calatayud

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 514 KB
• Volume: 265
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(92)85157-2

✦ Synopsis

Ahstraet A method for entrapment of reagents IS described The expcnmental procedure IS based on the dlsperslon of the reagent (MnOz) mto an unsaturated polyester solution and gnndmg the product to give the required particle size (300-400 pm) The reagent 1s packed mto a bed reactor (15 mm I d I and incorporated m a flow-mJectlon system The procedure was used for the mdlrect atomic absorption spectrometrlc determmatlon of lsomazld (OS-10 pg ml-') m solutions of pharmaceutical products, Hrlth little Interference from exclplents The measurements are based on the determmation of Mn2+ released on oxidation of the isomazld The relative standard deviation for the determmatlon of 5 fig ml-' of lsomazld IS 2 57% (n = 40) and the sample throughput IS 43 h-' Keywords Atomic absorption spectrometry, Flow mjectlon, Isomazld, Pharmaceutical Isomazld (lsomcotmlc acid hydrazlde) 1s a white, crystalline powder wgth a sweet taste at first and bitter after Its a bacterlostatlc drug and m high doses 1s active against mycobactermm species Isomazld 1s formulated for the treatment of pulmonary tuberculosis together with other antltuberculostatlc agents It also seems to be active for extrapulmonary Illnesses such as memngltls and gemto-urinary mfectlons [l] It 1s