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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut

✍ Scribed by Heleen A. Bardelmeijer; Mariët Ouwehand; Mirte M. Malingré; Jan H. Schellens; Jos H. Beijnen; Olaf van Tellingen


Publisher
Springer
Year
2001
Tongue
English
Weight
124 KB
Volume
49
Category
Article
ISSN
0344-5704

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## Abstract Paclitaxel (PTX) is a very effective drug in treating tumors. It disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis, leading to cell death by apoptosis. However, the effectiveness of PTX in cancer chemotherapy is hampered by drug resi