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Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma

✍ Scribed by Islam R. Younis; Samuel Malone; Henry S. Friedman; Larry J. Schaaf; William P. Petros


Publisher
Springer
Year
2008
Tongue
English
Weight
371 KB
Volume
63
Category
Article
ISSN
0344-5704

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## Background: This multicenter, phase ii trial was performed to evaluate the antitumor activity and toxicity of irinotecan (cpt-11) in patients with metastatic colorectal carcinoma that had recurred or progressed after 5-fluorouracil (5-fu)-based chemotherapy. ## Methods: Cpt-11 was given as a 9

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It has been reported that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11) and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have absorption characteristics of weakly basic drugs, suggesting that alkalization of the intestinal lumen might reduce reabsorpt