Enterobacterial attachment and effacement genotype among prospectively acquired putative enteropathogenic escherichia coli serogroups
✍ Scribed by N. Cimolai; A.C.H. Cheong
- Book ID
- 103042199
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 242 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-9120
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✦ Synopsis
Glardlasis is the commonest gastrointestinal parasitic disease in children. The protozoan adheres to the mucesni layer of the small intestine producing symptoms of diarrhea, malaise, abdominal pain; malabsorption and, in some cases, failure to thrive. The patbogenesis and pathophysiology of disease is net understood. Disaceharidase deficiency is clinically well-recognized in this disease and, although other n~,hantcm~ of tissue injury are possible, it has been suggested that diarrhea is based on an absorption defect.
To investigate this further we used the Mengolian gerbil animal model to study the effect of infection with two isolates of Gianiia duodenalis (syn G.lamblia) on enzymes of the small intestine. Levels of sucrase, maltase and lactase were measured at day 4, 6, 8 and 12 following inoculation and at the same intervals in control rodents. Lactase levels were decreased compared to controls. Sucrase and maltase levels were net lower in infected animals. Enzyme levels were