Enteric glia promote regeneration of transected dorsal root axons into spinal cord of adult rats
β Scribed by Shucui Jiang; Jian Wang; Mohammad I. Khan; Pamela J. Middlemiss; Hermelinda Salgado-Ceballos; Eva S. Werstiuk; Ray Wickson; Michel P. Rathbone
- Book ID
- 117100831
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 292 KB
- Volume
- 181
- Category
- Article
- ISSN
- 0014-4886
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Sensory axons interrupted in the dorsal roots of adult mammals are normally unable to regenerate into the spinal cord. We have investigated whether the introduction of a neurotrophin gene into the spinal cord might offer an approach to otherwise intractable spinal root injuries. The dorsal roots of
## Abstract Central nervous system axons regenerate into a Schwann cell implant placed in the transected thoracic spinal cord of an adult rat. The present study was designed to test whether these regenerated axons are capable of conducting action potentials. Following the transection and removal of