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Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA

✍ Scribed by Yarwood, A; Martin, P; Bowes, J; Lunt, M; Worthington, J; Barton, A; Eyre, S


Book ID
120595939
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
802 KB
Volume
14
Category
Article
ISSN
1466-4879

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The vitamin D receptor (VDR) elicits a transcriptional response to 1,25-dihydroxyvitamin D 3 by binding to specific response elements (VDRE) in the promoter of target genes. Retinoic X receptor (RXR) is required for formation of the VDR-VDRE complex when VDR is supplied at physiologic concentrations