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Enhancing the Proline Effect: Pseudo-Prolines for Tailoring Cis / Trans Isomerization

✍ Scribed by Keller, Michael; Sager, Cédric; Dumy, Pascal; Schutkowski, Mike; Fischer, Gunter S.; Mutter, Manfred

Book ID
120415343
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
85 KB
Volume
120
Category
Article
ISSN
0002-7863

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Nmr studies of the rates of proline cis–
Nmr studies of the rates of proline cis–trans isomerization in oligopeptides
✍ Christoph Grathwohl; Kurt Wüthrich 📂 Article 📅 1981 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 593 KB

## Abstract ^1^H‐Nmr was used to measure the rate of __cis__–__trans__ interconversion of __X__‐Pro bonds in linear and cyclic oligopeptides. __k__(cis → trans) = 2.5 × 10^−3^ s^−1^ at 25°C was found for the zwitterionic form of H‐Ala‐Pro‐OH, in good agreement with earlier measurements. Replacement