The human monoclonal antibody (humAb) 2F5 is a potent candidate for immunotherapy of HIV-1. The xenohybridoma derived humAb 2F5 is of IgG3 kappa isotype. Generally, IgG1 isotype has a longer half-life (β€clearance) in humans than IgG3. Therefore the isotype was switched to an IgG1 by ligation of the
Enhancing the avidity of a human recombinant anti-HIV-1 monoclonal antibody through oligomerization
β Scribed by P. K. Tsai; C. J. Burke; J. W. Irwin; M. W. Bruner; C. R. Middaugh; J. A. Kessler II; L. J. Boots; A. J. Conley; J.-S. Tung; G. F. Hollis; G. E. Mark
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 532 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0022-3549
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