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Enhancing resistance and modulation of humoral immune response to experimentalCandida albicansinfection by patulin

✍ Scribed by L. Escoula; D. Bourdiol; M. D. Linas; P. Recco; J. P. Seguela

Publisher
Springer Netherlands
Year
1988
Tongue
English
Weight
265 KB
Volume
103
Category
Article
ISSN
0301-486X

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✦ Synopsis

Mice receiving patulin (10 mg/kg) from 1 to 4 days showed enhancing resistance to intraperitoneal challenge with 108 viable Candida albicans at day 2. Resistance to. C. albicans infection (106 blastospores) appeared to be unchanged after cyclophosphamide oral administration (60 mg/kg). Immunoglobulins levels (IgA, IgM, IgG) are marked depressed (10 to 75~ in mice infected and/or treated by patulin and cyclophosphamide.

The results show that an increase of neutrophil count may be among the factor underlying the late increase in resistance to C. albicans after administration of patulin.

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