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Enhancing effect of a congenital disorder in methionine metabolism on the development of spontaneous hepatitis and hepatoma in LEC rats

✍ Scribed by Makihiko Kuhara; Saburo Horikawa; Yoshihiko Kawarada; Kunihiko Terada; Naoyuki Miura; Kinji Tsukada; Naoyuki Taniguchi; Toshihiro Sugiyama

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 135 KB
Volume: 10
Category: Article
ISSN: 0896-548X
DOI: 10.1002/(sici)1520-670x(1997)10:2<61::aid-jtra3>3.0.co;2-7

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✦ Synopsis

A marked decrease in S-adenosylmethionine (AdoMet) content and a significant decrease in methionine and glutathione contents in the LEC rat liver were observed between the 8th and 12th weeks before start of spontaneous hepatitis. The decreased levels were enhanced by an ethionine or choline-deficient diet, and changes were associated with a decrease in AdoMet synthetase expression at both the protein and mRNA levels as determined by Western blot and Northern blot experiments. These results suggest that a congenital disorder in methionine metabolism enhances the development of spontaneous hepatitis and hepatoma in LEC rats.

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