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Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life and Intracellular Targeting Strategies with a Strategy to Boost CD4 + T Cells

✍ Scribed by Kim, Daejin; Hoory, Talia; Wu, T.-C.; Hung, Chien-Fu


Book ID
120200854
Publisher
Mary Ann Liebert
Year
2007
Tongue
English
Weight
535 KB
Volume
18
Category
Article
ISSN
1043-0342

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## Abstract Dendritic cell (DC)‐based vaccines have become important in immunotherapeutics as a measure for generating antitumor immune responses. We have previously demonstrated that linkage of the antigen gene to a lysosomal targeting signal, a sorting signal of the lysosome‐associated membrane p