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Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins

โœ Scribed by Hiroki Hamada; Kohji Ishihara; Noriyoshi Masuoka; Katsuhiko Mikuni; Nobuyoshi Nakajima

Book ID
115031847
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
209 KB
Volume
102
Category
Article
ISSN
1389-1723

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Enhanced solubility of paclitaxel using water-soluble and biocompatible 2-methacryloyloxyethyl phosphorylcholine polymers
โœ Konno, Tomohiro ;Watanabe, Junji ;Ishihara, Kazuhiko ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 175 KB

## Abstract The purpose of this study was to enhance the waterโ€solubility of paclitaxel (PTX) using an amphiphilic 2โ€methacryloyloxyethyl phosphorylcholine (MPC) polymer as the solubilizer. PTX is an antineoplastic drug effective for various cancers, especially for ovarian and breast cancers. Howev