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Enhancement of type IV collagenases by highly metastatic variants of HT1080 fibrosarcoma cells established by a transendothelial invasion systemin vitro

✍ Scribed by Tomoko Okada; Jun Li; Masato Kodaka; Hiroaki Okuno

Book ID
110237766
Publisher
Springer
Year
1998
Tongue
English
Weight
392 KB
Volume
16
Category
Article
ISSN
0262-0898

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Monoclonal antibodies (MAbs) against human type-IV collagenase were developed and used for studies on enzyme activity and tumor-cell invasion in vitro. Fifteen MAb clones were generated against the enzyme purified from serum-free culture medium of human melanoma cells (A2058). Five clones affecting