Enhancement of rectal absorption of drugs by adjuvants

✍ Scribed by Toshiaki Nishihata; J. Howard Rytting; Takeru Higuchi

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 240 KB
• Volume: 69
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600690641

✦ Synopsis

by drying at 26' at a pressure of >3 torr (13% RH) or the equivalent at a higher temperature, then only the last five points would be involved and the shape would lose the initial sigmoid nature.

These comments are confined to situations where no gross swelling or pore-size distortion occurs during moisture uptake (7, 8). Furthermore, the solubility must be sufficiently low so that no significant volume changes or vapor pressure changes can result from dissolution.