Enhancement of pulmonary metastases by x-irradiation in rats bearing mammary cancer
✍ Scribed by Thomas L. Dao; Hiroshi Yogo
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 571 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Whether x-irradiation increases the incidence of pulmonary metastases in rats bearing carcinogen-induced mammary cancers was investigated. The experimental data show that local x-irradiation prior to inoculation of a suspension o E mammary tumor cells significantly increased the incidence of pulmonary metastases in the irradiated lungs only. If the irradiation is administered after tumor cell inoculation, the incidence of pulmonary metastasis in the irradiated lungs is not significantly different from the control groups. Whole body irradiation does not seem to have an effect on pulmonary metastases. The results suggest that increase in incidence of pulmonary metastasis is due to a local effect of irradiation on the pulmonary tissue and is not an effect of general depression of host-immune mechanism. The exact mechanism by which irradiation enhances pulmonary metastases is not entirely clear.