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Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib

✍ Scribed by Angela Ferrario; Sophia Lim; Frank Xu; Marian Luna; Kevin J. Gaffney; Nicos A. Petasis; Axel H. Schönthal; Charles J. Gomer

Book ID
116335599
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
531 KB
Volume
304
Category
Article
ISSN
0304-3835

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## Abstract Many tumors constitutively express high levels of the inducible form of proinflammatory enzyme, cyclooxygenase‐2 (COX‐2). Increased COX‐2 expression is associated with tumor cell resistance to many cytotoxic chemotherapy drugs. Furthermore, increased resistance to cytotoxic antitumor dr