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Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase

✍ Scribed by Andreas P. Sutter; Kerstin Maaser; Bastian Gerst; Antje Krahn; Martin Zeitz; Hans Scherübl

Book ID
113487088
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
395 KB
Volume
67
Category
Article
ISSN
0006-2952

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Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells
✍ Andreas P. Sutter; Kerstin Maaser; Michael Höpfner; Bettina Barthel; Patricia Gr 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 960 KB

Esophageal cancer is the most markedly increasing tumor entity in Western countries. Due to very poor 5-year-survival, new therapeutic approaches are mandatory. Peripheral benzodiazepine receptors (PBR) have been implicated in growth control of various tumor models, but they have not been studied ye