Enhancement of passive avoidance learning through small doses of intra-amygdaloid physostigmine in the young rat. Its relation to the development of acetylcholinesterase
✍ Scribed by Vincent Dumery; Paul Derer; Denise Blozovski
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 889 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0012-1630
No coin nor oath required. For personal study only.
✦ Synopsis
Passive avoidance learning was studied in young rats 7-20 days old, in control conditions and after bilateral injections of physostigmine into the lateral amygdaloid nucleus. Acquisition in controls was possible from postnatal Day 8 on, progressed markedly after Day 11, and nearly reached maturity by Day 20. Physostigmine differentially altered acquisition depending on the dose: facilitation with low doses, no effect with moderate doses, and impairment with high doses. Enhanced learning through small doses of physostigmine was observed at all ages from Day 8 on, and was greater with0.2 p g than with 0.1 pg. Maturation of the cholinergic innervation of the amygdaloid region was also studied between Days 9-20 using acetylcholine-esterase histochemistry. The results suggest that passive