Repopulation of the cirrhotic liver with disease-resistant hepatocytes could offer novel therapies, as well as systems for biological studies. Establishing whether transplanted hepatocytes can engraft, survive, and proliferate in the cirrhotic liver is a critical demonstration. Dipeptidyl peptidase
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Enhancement of P-Glycoprotein Expression by Hepatocyte Transplantation in Carbon Tetrachloride-Induced Rat Liver
โ Scribed by Ming Yu; Weiguang Zhang; Lihua Qin; Long Tian; Changman Zhou
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Tongue
- English
- Weight
- 940 KB
- Volume
- 293
- Category
- Article
- ISSN
- 1932-8486
- DOI
- 10.1002/ar.21160
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Mammalian liver exhibits expression of members of the family of multidrug resistance (mdr) transporters (P-glycoproteins). P-glycoprotein isoforms encoded by mdr1 genes participate in extrusion of an array of xenobiotics into the bile. Induction of mdr1b mRNA expression has been shown to occur in ra