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Enhancement of lung adenoma formation by neonatal thymectomy in mice treated with 7,12-dimethylbenz(a)anthracene or urethan

✍ Scribed by Nathan Trainin; Mariana Linker-Israeli; Myra Small; Louise Boiato-Chen

Publisher
John Wiley and Sons
Year
1967
Tongue
French
Weight
690 KB
Volume
2
Category
Article
ISSN
0020-7136

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✦ Synopsis

The influence of neonatal thyniectomy on lung adenoma formation in mice was investigated. S W R and Swiss mice thymectomized at 3 days of age and given a single dose of 7,12-dimethylbenz (a)anthracene ( D M B A ) or urethan showed signiJcantly higher incidences of tumors than did intact controls, when examined at various intervals after the carcinogenic treatment. These diferences in the yield of tumors were manifested as early as I0 weeks after urethan administration. Levels of hemolysins and hemagglutinins in response to sheep erythrocytes were decreased in thymectomized mice as compared with normal animals.

The probable relationship between enhanced susceptibility to chemical carcinogens and immunological deficit of neonatally thymectomized mice is discussed.

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Inhibition by germ-free status of develo
Inhibition by germ-free status of development of liver and lung tumours in mice exposed neonatally to 7,12-dimethylbenz(A)anthracene: Implications in relation to tests for carcinogenicity
✍ F. J. C. Roe; G. A. Grant 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 French ⚖ 906 KB

## Abstract Germ‐free (GF) status significantly “protected” male C3H mice from the early (before 40 weeks) development of liver‐cell tumours in response to 7,12‐dimethylbenz(a)anthracene (DMBA) given shortly after birth. GF status significantly protected C3H mice of both sexes from the early develo