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Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide

✍ Scribed by Johannes Oehlke; Gerd Wallukat; Yvonne Wolf; Angelika Ehrlich; Burkhard Wiesner; Hartmut Berger; Michael Bienert


Book ID
110915157
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
259 KB
Volume
271
Category
Article
ISSN
1432-1327

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Cellular uptake and biological activity
✍ Yvonne Turner; Gerd Wallukat; Pille Säälik; Burkhard Wiesner; Stephan Pritz; Joh 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 383 KB

## Abstract A 12‐mer peptide nucleic acid (PNA) directed against the nociceptin/orphanin FQ receptor mRNA was disulfide bridged with various peptides without and with cell‐penetrating features. The cellular uptake and the antisense activity of these conjugates were assessed in parallel. Quantitatio