Enhancement of integrins by interleukin-1α, and their relationship with metastatic and invasive behavior of human pancreatic ductal adenocarcinoma cells

Upmodulation of αvβ1 integrin expression

Upmodulation of αvβ1 integrin expression on human tumor cells by human interleukin for DA cells/leukemia inhibitory factor and oncostatin M: Correlation with increased cell adhesion on fibronectin

✍ Dominique Heymann; Jean Harb; Sophie Ringeard; Fréadéric Blanchard; Danielle Las 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 972 KB

## Abstract Integrins belong to a large family of heterodimeric membrane glycoproteins which mediate cell‐cell or cell‐extracellular matrix interactions. These interactions could play a major role during the migration of tumor cells across the extracellular matrix and vascular endothelium and would