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Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres

✍ Scribed by Manish Diwan; Mohsen Tafaghodi; John Samuel

Book ID: 114161956
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 629 KB
Volume: 85
Category: Article
ISSN: 0168-3659
DOI: 10.1016/s0168-3659(02)00275-4

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CpG ODN are toll-like receptor 9 (TLR9) agonists that can enhance antigen presentation by antigen presenting cells (APCs) such as dendritic cells (DCs). The most potent antigen-specific responses are seen when CpG ODN and the antigen are co-localized in the same APC. CpG ODN-antigen fusion molecules