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Enhancement of human immunodeficiency virus production by natural lymphotoxin

✍ Scribed by Toshifumi Matsuyama; Yoshiaki Hamamoto; Susumu Kobayashi; Masashi Kurimoto; Jun Minowada; Nobuyuki Kobayashi; Naoki Yamamoto

Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
443 KB
Volume
177
Category
Article
ISSN
0300-8584

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✦ Synopsis

The effect of natural lymphotoxin (n-LT) on CD4+ MOLT-4 cells and those cells producing human immunodeficiency virus (HIV), MOLT-4/HIVHTLV-IIIB cells, was studied. Four days after treatment with n-LT, a significant cytotoxic/cytostatic effect was observed predominantly on MOLT-4/HIVHTLV-IIIB cells. Furthermore, with regard to the production of HIV, an almost 3- to 5-fold increase of viral particles was observed in MOLT-4/HIVHTLV-IIIB cells 6 h after treatment with n-LT. These data indicate the possibility that this cytotoxic factor is one of the responsible molecules in the pathogenesis of the acquired immunodeficiency syndrome (AIDS).

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Long-term survival and virus production
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✍ Stefano Aquaro; Patrizia Bagnarelli; Tania Guenci; Andrea De Luca; Massimo Cleme πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 173 KB

## Abstract The role of macrophages in the pathogenesis and progression of human immunodeficiency virus (HIV)‐related infection is substantiated by in vitro and in vivo evidence. The unique ability to survive HIV infection and produce viral particles for long periods is postulated. Detailed studies